Christ certainly felt the burden of a city that refused His grace (Luke 19:41). Jerusalem had every opportunity to repent, having seen great miracles and having heard the Lord's greatest sermons. The knowledge that Jerusalem would finally reject and crucify Him caused Jesus to weep over a lost opportunity.
Paul also felt heartsick over Israel's rejection of the Gospel: "My heart is filled with bitter sorrow and unending grief for my people, my Jewish brothers and sisters. I would be willing to be forever cursed-cut off from Christ!-if that would save them" (Romans 9:2-3).
Have you ever thought that a certain person would surely repent after hearing a particular sermon or experiencing an especially painful situation in his life, and yet he did not? Intercession can arise from deferred hope, knowing that God is waiting to bless, but human beings are resisting. The pain and agony of watching others miss God's best in their lives should be turned into a continual prayer on their behalf.
Keep on standing for your lost loved ones. As long as they are alive and breathing, there is still hope. Imagine the joy you will experience when they turn their lives over to God!